Dr. Elbert Lewis Myles, Jr.
Professor
Department of Biological Sciences
College of Life & Physical Sciences
Contact Information:
Office Location: Harned Hall, Room 213; Lab, 302/304
Telephone: 615-963-5789
Fax: 615-963-5796
E-mail: emyles@tnstate.edu
Education
Tennessee State University, Nashville, TN, Biological Sciences B.S. 1974
Tennessee State University, Nashville, TN, Biological Sciences M.S. 1976
University of Arizona, Tucson, Arizona, Committee of Genetics Ph.D. 1985
Post-Doctoral Fellow, Columbia University Med School, N. Y. 1984 – 1986
Research Associate for Cooperative Agricultural Research Prog. 1986 - 1989
Research Interests There are a number of molecules/secondary compounds derived from plants, and bacteria isolated as anticancer and antimicrobial agents. Many of these compounds are thought to have anti-tumor and/or bacterial activity, however, they are lacking experimental evidence to support these concepts. We believe there is a greater possibility of finding biological activity among plants with ethno-medicinal value rather than from plants that are randomly selected. Therefore, based on this rationale the major aims underlying our study are to identify bioactive plants based primarily on their ethnomedicinal usage and rapidly conduct efficient and accurate bioassay screening methods. With respect to anticancer/antibacteria drug screening, for cytotoxicity and cell viability assays would provide sufficient preliminary data to facilitate the identification of such plants.
Publications
Amara, S., Lopez, K., Banan, B., Brown, S-K., Whalen, M., Myles, E., Ivy, M.T. , Johnson, T., Schey, K.L., and V. Tiriveedhi V. 2015. Synergistic effect of pro-inflammatory TNFa and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis. Molec. Immunol. 64: 26-35.
Mehta, T., Vercruysse, K., Johnson, T., Ejiofor, A.O., Myles, E., and Q.A. Quick. 2015. Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration. Mol. Med. Rep. 12(1): 1443-8. E. pub 2015 Mar 20.
Platt, D., Amara, S., Mehta, T., Vercuyssee, K., Myles, E.L., Johnson, T. and V. Tiriveedhi (2014). Violacein inhibits matrix metalloproteinase mediated CXCR4 expression: Potential anti-tumor effect in cancer invasion and metastasis. Biochem. Biophys. Res. Comm. 455: 105-112.
Hembree. W.C., H.N. Nagler, J.S. Fang, E.L. Myles and G.M. Jagiello. 1988. Infertility in a patient with abnormal spermatogenesis and in utero DES exposure. International Journal of Fertility 33(3):173.
E. L. Myles, Jr. and J.E. Endrizzi. 1989. Aneuploids induced by deficiencies of chromosome 9 and analysis of the time of nondisjunction in cotton. Genome. 32:12.
E. Lewis Myles, Brenda Jordan, Clifton Randell, Crystal Barbee, Deborah Long, Sarabjit Bhatti and Roger Sauve. 2000. Innovative Use Of Purple Cone Flower (Echinacea) As An Anti-Cancer Source, Proceedings of the Southern Nursery Association. Vol 45 (3) 258-260
Deborah Long, Mary, Cherry, Sara Bhatti, RogerSuave, E. Lewis Myles. 2001 HPLC Analysis of active constituents in three species of hypericum. Proceedings of the Southern Nursery Association. Vol. 46 (2) 110-112.
M.T. Mmbaga, F.J. Avila, E.F. Howard, and E.L. Myles. 2006. Accumulation of a Protein Associated with Plant Defense in Powdery Mildew Resistant Dogwood (Cornus florida) Journal Of Environmental Horticulture Volume 24, Issue 2
C. Edwards - P. Armstrong - G.d. Goode - C. Mtshali - S. Williams - E.L. Myles - B. Washington -2007. 6. Cross-Talking Between Calcium And Histamine In The Expression Of Mapks In Hypertensive Vascular Smooth Muscle Cells. Cellular and Molecular Biology Vol 53(4) 61-66
J.B. Shaw - Q. Cai - C. Mtshali - E.L. Myles - B. Washington. 2007. Heterogeneity Of Histamine H3 Receptor Genomic Expression In The Cerebral Cortex Of Spontaneously Hypertensive Rat Cellular and Molecular Biology Vol 53 (4): - 45-50
A.l. Johnson - G.d. Goode - C. Mtshali - E.L. Myles - B. Washington. 2007. Protein Kinase C- Α/ßii, Δ, And Ζ/Λ Involvement In Ethanol-Induced Mapk Expression In Vascular Smooth Muscle CellsCellular and Molecular Biology, Vol 53 (4): 38-44
Olugbeminiyi O. Fadeyi , Saudat T. Adamson , E. Lewis Myles , Cosmas O. Okoro ,2008. Department of Chemistry, Department of Biological Sciences, Bioorganic & Medicinal Chemistry Letters 18 (2008) 4172–4176
Gary, T, Butler, J, Arino de la Rubia, L., Myles, E. L., Bradford, K, Kirven-Brooks, M., Deballos, R. M., Taylor, L, Bell, B and Coulter, G. 2009 The NASA Astrobiology Institute-Minority Institution Research Support Program: Strengthening the Astrobiology Community. Bioastronomy: Molecules, Microbes and Extraterrestrial Life. ASP conference Series Vol. 420, p477-484,
Oluropo C. Agbaje , Olugbeminiyi O. Fadeyi, S. Adamson Fadeyi, E. Lewis. Myles, Cosmas O. Okoro ,2010; Synthesis and in vitro cytotoxicity evaluation of some fluorinated hexahydropyrimidine derivatives; Bioorganic & Medicinal Chemistry Letters 21 (2011) 989–992
Courses Taught
Principles of Genetics
Molecular Genetics
Advanced Genetics
Environmental Genetics
Plant Physiology
Cell Biology
Molecular Biology
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Biology