Dr. Sarika Saraswati
Assistant Professor
Department of Biological Sciences
College of Life & Physical Sciences
Contact Information:
Office Location: Harned Hall
FAX: 615-963-5786
Email: ssaraswa@tnstate.edu
Education
(PhD) Biochemistry and Molecular Biology- University of Arkansas for Medical Sciences (UAMS)
(M.S.) Botany-University of Allahabad
(B.S.) Biological Sciences- University of Allahabad
Research Area Tissue regeneration
Publications
Saraswati S, Lietman C D∗, Li B, Mathew S, Zent R, and Young PP$. Small proline-rich repeat 3 is a novel coordinator of PDGFRβ and Integrin β1 crosstalk to augment proliferation and matrix synthesis by cardiac fibroblasts. FASEB J. 2020 April, https://doi.org/10.1096/fj.201902815R
Melzer M, Beier D, Young P P. and Saraswati S. Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts Journal of Visualized Experiments 2020 March; https://dx.doi.org/10.3791/60909
Saraswati S , Marrow SMW, Watch L A, and Young P P. Identification of a pro-angiogenic functional role for FSP1 positive fibroblast subtype in wound healing. Nat Commun. 2019 Jul 9;10(1):3027. doi: 10.1038/s41467-019-10965-9.
Bastakoty D, Saraswati S, Joshi P, Atkinson J, Feoktistov I, Liu J, Harris JL, Young PP. Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell Stem Cells Regen Med. 2016 Nov;2(2). doi: 10.16966/2472- 6990.111. Epub 2016 May 30.
Bastakoty D, Saraswati S, Cates J, Lee E., Nanney B L, and Young PP. Inhibition of Wnt/β- catenin pathway promotes regenerative repair of cutaneous and cartilage injury. FASEB J. 2015 Aug 12. pii: fj.15-275941.
Saraswati S, Guo. Y, Atkinson. J, and Young PP. Prolonged hypoxia induces MCT4 expression in MSCs resulting in a secretome that is deleterious to cardiovascular repair. Stem Cells. 2015 Apr;33(4):1333-44. doi: 10.1002/stem.1935
Deskins DL, Bastakoty D, Saraswati S, Shinar A, Holt GE, and Young, PP. Human Mesenchymal Stem Cells: Identifying Assays to Predict Potency for Therapeutic Selection. Stem Cells Translational Medicine. 2013 Feb;2(2):151-8. doi: 10.5966/sctm.2012-0099. Epub 2013 Jan 29
Saraswati S, Deskins, DL, Holt, GE, and Young, PP. Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells. Wound Repair and Re- generation. 2012 Mar-Apr;20(2):185-93. doi: 10.1111/j.1524-475X.2012.00767.x. Epub 2012 Feb 14.
Teaching
BIOL 4110 Molecular Genetics