Punam Paul
Punam's Research
We have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because this receptor is highly expressed in a variety of tumor types. b-cyclodextrin and folic acid were connected through a linker [4-carbaldehyde-4-hydroxymethyl-2,2-bipyridine] by formation of Schiff base and an ester, respectively. Our targeted synthetic products were confirmed by NMR spectroscopy. We anticipate that our synthetic products would confer cancer-cell-specific drug delivery as well as desired properties such as nanoparticle formation. We have also synthesized biotin appended cyclodextrin (γ cyclodextrin and HP-γ-CD) to analyze fluorescence properties of cyclodextrin derivatives.
