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Razzak

Research Focus

There is a continuing interest in the design and synthesis of molecules that efficiently bind to DNA and cleave it. In particular, the study of organic chelating agents containing nitrogen and sulfur as the donor atoms and their metal complexes has become a subject of intensive investigation. In this regard, the use of bidentate N,N chelating agents such as 1, 10-phenanthroline (phen) has played an important role in synthetic and medicinal chemistry [1]. 1,10-Phenanthroline has also been used extensively as a ligand in both analytical and preparative coordination chemistry as well as in the preparation of many mixed-ligand complexes [2]. 1,10- Phenanthroline and ligands derived from it as well as some of their metal complexes have also been found to be widely used in areas such as molecular catalysis, solar energy conversion, calorimetric analysis, herbicides, molecular recognition, self-assembly, antineoplastic agents, and nucleic acid probes [3]. It has been found that Schiff bases formed by condensation of S-alkyl/aryl esters of dithiocarbazaic acid with heterocyclic aldehydes and ketones contain both ‘hard’ nitrogen and ‘soft’ sulfur donor atoms [4]. Consequently, they are capable of forming stable complexes with a wide vriety of metal ions, some of which have also been found to exhibit interesting physico-chemical properties and potentially useful chemotherapeutic properties [5].

It has also been reported that polymeric metalcomplexes of 1,10-phenanthroline-based liands containing bithiazole rings exhibit significant magnetic properties [6]. Since organic and polymeric magnets offer advantages over traditional magnets because of the diversity of their structures, low density, low magnetic loss and process of preparation without metallurgy at high temperature, studies involving the synthesis of Schiff bases using 1,10-phenanthroline-2,9-dicarboxaldehyde and sulfur-containing primary amines deserve more attention. We, therefore, have undertaken the synthesis and characterization new Schiff bases formed from 1,10-phenanthroline-2,9-dialdehyde and some sulfur-containing amines and study their antibacterial property.

 Publications:

Razzak, M. , Karim, M. , Hoq, M. and Mirza, A. (2015) New Schiff Bases from 6,6’-Diformyl-2,2’-Bipyridyl with Amines Containing O, S, N and F: Synthesis and Characterization. International Journal of Organic Chemistry, 5, 264-270. doi: 10.4236/ijoc.2015.54026.

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