Dr. Mohammad Karim

 

Karim2   

Professor, Organic Chemistry
Department of Chemistry

Contact Information:
Phone: 615-963-5344
Fax: 615-963-5326
mkarim@tnstate.edu

Karim's Research

KARIM'S RESEARCH GROUP

KARIM'S RESEARCH GROUP

  Research Group
Karim Research Group
Nadim_Research

Graduate Students

Arifuzzaman -Received PhD from Iowa Sate University, Ames, IA. Currently working at University of Connecticut as Postdoctoral Fellow

Zinia Jaman -Received PhD from Purdue University, Lafayette, IN. Joined at DuPont

Anisur Rahman -Received PhD from University of South Carolina, Columbia, SC. Currently working as Postdoctoral Fellow at the same University.

Rejaul Hoq - Currently pursuing PhD at Purdue University, Lafayette, IN

Md. Razzak -Graduated with a MS degree and decided to go back to his own country, Bangladesh

Kholoud Alhaidari -Graduated, went back to her own country

Zaina Alqahtani -Graduated, went back to her own country

Shafiqul Islam -Currently pursuing PhD at Temple University, Philadelphia.

Punam Kumar Paul - Currently pursuing PhD at Wayne State University, Detroit, Michigan

Nadim Russel - Currently pursuing PhD at Temple University, Philadelphia, PA.

 

 

Areas Of Interest

Synthetic organic chemistry, development of new synthetic strategy, natural product synthesis, synthesis of anticancer and anti-AIDS agents.

       1.          Synthesis of Schiff’s Bases

       2.          Synthesis of Curcumol and Related Natural products

       3.          Synthesis of Cembranoid Diterpenes

PUBLICATIONS:

  • N-[(E)-Quinolin-2-yl­methyl­idene]-1,2,4-triazol-4-amine hemihydrate. N. N. M. Shahri , N. H. S. Omar Ali , M. H. Sheikh Abdul Hamid , A. H. Mirza , A. Usman , M. R. Hoq and M. R. Karim . IUCrData (2020). 5 , x200134, https://doi.org/10.1107/S2414314620001340

  • Synthesis of Folate-appended β-Cyclodextrin for Cancer Targeting Drug Delivery Nadim S. Russel*, Punam K. Paul,* Mohammad Karim*, Byeongwoon Song**, Chemistry Day 2019. *Department of Chemistry, Tennessee State University, Nashville, TN 37209. **Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN 37208

  • Synthesis of Folate-appended β-Cyclodextrin with 4-carbaldehyde-4-hydroxymethyl-2,2-bipyridine as a linker for Cancer Targeting Drug Delivery and synthesis of Biotin-appended γ cyclodextrin and HP-γ-CD for measurement of fluorescence intensities. Punam K.Paul,* Mohammad Karim*, Byeongwoon Song**, Chemistry Day 2019. *Department of Chemistry, Tennessee State University, Nashville, TN37209 **Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN 37208

  • Triosmium Clusters Stabilized By Benzoxazol-2-Thiolate Ligand: Synthesis, X-Ray Crystal Structure and Thermal Isomerization. Shafikul Islama, Mohammad Julhas A. Miaha, Md. Manzurul Karima,*, Mohammad R. Karimb,* and Tasneem A. Siddiqueeb. Polyhedron, 2019 Submitte
  • Synthesis of Folate-appended b-Cyclodextrin using Phenanthroline as Linker for Cancer Targetting Drug Delivery. Nadim S. Russel, Punam K. Paul, Mohammad R. Karim, Byeongwoon Song, IJOC, 2019, Vol. 9, No. 1, pp 47-66. DOI: 10.4236/ijoc.2019.91005 
  • H-Bonding plays a key role in the formation of stable hemiaminals. Md. Shafiqul Islam, Md. Razzak, Mohammad Karim, Aminul H. Mirza, Tetrahedron Letters, 2017, http://dx.doi.org/10.1016/j.tetlet.2017.01.086
  • Schiff Bases as Anti-cancer Drugs: Synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole, Phenathroline and Bipyridine Dicarboxaldehydes. Md. Shafiqul Islam,1 Mohammad R. Karim*1, William Boadi,1 Seyi Falekun,1 Aminul H. Mirza.2 Advances in Biological Chemistry, 2016. pp 180-192, DOI: 10.4236/abc.2016.66016  
  • Synthesis, structures and spectroscopic properties of some tin(IV) complexes of the 2-acetylpyrazine Schiff bases of S-methyl- and S-benzyldithiocarbazate; Aminul Mirza, Malai Haniti Sheikh Abdul Hamid, PhD, MSc, BSc; Ampuan Norhidayati Ampuan Hj Said, BSc, MSc; Mohammad R Karim, BSc, MSc, PhD; Md Arifuzzaman, BSc, MSc; Mohammad Akbar Ali, BSc, MSc, PhD; Paul V Bernhardt, BSc, MSc, PhD; Journal of  Inorganica Chimica Acta, (2016), doi: http://dx.doi.org/10.1016/j.ica.2016.09.038.
  • A. Azim Jambol1, Malai Haniti S. A. Hamid1*, Aminul H. Mirza1, Md. Shafiqul Islam,2 Mohammad R. Karim2. Some Novel Schiff bases from Pyruvic Acid with Amines containing N & S donor atoms: Synthesis, Spectral Studies and X-Ray Characterization. 1Department of Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam, 2Department of Chemistry, Tennessee State University, Nashville, USA. Email*: haniti.hamid@ubd.edu.bn. IJOC, 2017, 7, 42-56
  • Razzak, M. , Karim, M. , Hoq, M. and Mirza, A. (2015) New Schiff Bases from 6,6’-Diformyl-2,2’-Bipyridyl with Amines Containing O, S, N and F: Synthesis and Characterization. International Journal of Organic Chemistry, 5, 264-270. doi: 10.4236/ijoc.2015.54026.
  • Synthesis of Schiff bases from 2,2'-dipyridyl-5,5'-dialdehyde with thiocarbazates. Md. Rejaul Hoq, Mohammad R. Karim . University-Wide Research Day, April 2015
  • Synthesis, Characterization and Antibacterial Study of Schiff Bases derived from 2,2'-bipyridine-5,5'-dicarbaldehyde and Sulfur Containing Amines, ACS National Meeting, Denver, CO. Md. Rejaul Hoq, Mohammad Karim; Department of Chemistry, Tennessee State University, 3500 John A. Merritt Blvd. Nashville, TN-37209           
  • Synthesis and Antibacterial Study of Schiff Bases derived from 2,2'-bipyridine-5,5'-dicarbaldehyde and Sulfur Containing Amines, SERMACS, Nashville, 2014. Md. Rejaul Hoq, Mohammad Karim; Department of Chemistry, Tennessee State University, 3500 John A. Merritt Blvd. Nashville, TN-37209
  • Synthesis of Schiff bases from 2,2'-dipyridyl-5,5'-dialdehyde with thiocarbazates. Md. Rejaul Hoq, Mohammad R. Karim, Aminul H.Mirza, Korsi Dumenyo. International Journal of Organic Chemistry, 2015, 5, 29-36.
  • Synthesis of Loratadine and some of it's amide derivatives as cytotoxic agents. Lipiar Khan Mohammad Osman Goni, Nahida Akter, Md. Rabiul Islam, Anisur Rahman, Mohammad Karim. International Journal of Medicinal Chemistry & Analysis, 2015, vol 5, issue 2, pp 68-73.
  • Zn(II) Catalyzed Efficient Synthesis of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole. Md. A. Rahman, Mohammad R. Karim**, Md. Arifuzzaman, Tasneem A. Siddiquee*, Aminul H. Mirza. Tetrahedron Letters, 2014, 55, 3267-73.
  • Synthesis of Schiff bases from 2,2'-dipyridyl-5,5'-dialdehyde with thiocarbazates. Md. Rejaul Hoq, Mohammad R. Karim, Aminul H.Mirza, Korsi Dumenyo. International Journal of Organic Chemistry, 2015, 5, 29-36
  • Antibacterial activities of new Schiff bases and intermediate Silyl compounds sythesized from 5-substituted-1,10-phenanthroline-2,9-dialdehyde. Zinia Jaman, Mohammad R. Karim, Korsi Dumenyo, Aminul H. Mirza. Advances in Microbilogy, 2014, 4, 1140-1153.
  • Synthesis, spectroscopy and X-ray crystal structures of some zinc(II) and cadmium(II) complexes of the 2-pyridinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazates  Aminul Huq Mirzaa, Malai Haniti S. A. Hamida, Sazwani Aripina , Mohammad Rezaul Karimb, Md. Arifuzzamanb, Mohammad Akbar Alia* , Paul V. Bernhardtc Polyhedron, 2014, 74, 16-23.
  • 2,9-Bis(5-sulfanylidene-4,5-di­hydro-1,3,4-oxa­diazol-2-yl)-1,10-phenanthroline dimethyl sulfoxide disolvate. M. A. Rahman, M. Karim, M. Arifuzzaman, T. Siddiquee and L. M. Daniels, Acta Cryst. (2014). E70, o321-o322  [ doi:10.1107/S1600536814003304 ]  .
  • ZnCl2 Catalyzed Efficient Synthesis of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole. Md. A. Rahman1, Mohammad R. Karim1*, Md. Arifuzzaman,2 Tasneem A. Siddiquee1, Aminul H. Mirza3. Tetrahedron Letters, 2014, 55, 3267-3273.
  • Octyl-(2E)-2-[2-(diphenylphosphanyl)benzylidene]hydrazinecarbodithioate:   Izuddin Asri,   Malai Haniti S. A.  Hamid,   Aminul Huq Mirza,   Mohammad Akbar Ali and Mohammad Rezaul Karim* Acta Crystallographica Section E, 2014, ID: 4051045.
  • Synthesis and Characterization of New Schiff bases formed by Condensation of  2,9-Phenathroline-1,10-dialdehyde  with Sulfur-containing Amines. , 247th ACS National Meeting, March 16-20, 2014, Dallas, Texas [ORGN006]
  • ZnCl2 catalyzed efficient synthesis of 1,3,4-oxadiazole, 247th ACS National Meeting, March 16-20, 2014, Dallas, Texas [ORGN006]
  • Synthesis of 5-Substituted 2, 9-Dimethyl-1,10-Phenanthroline Dialdehydes and Their Schiff bases with Sulfur-containing Amines. Zinia Jaman*, Mohammad R. Karim**, Tasneem A. Siddiquee*, Aminul H. Mirza†, Mohamad A. Ali†, International Journal of Organic Chemistry 2013, Vol 3 No. 3.
  • Synthesis and structure of dimeric Copper (I) complex from bis[(2,2’)-Dimethyl 2,2’-(1,10- Phenanthroline-2,9-diyl)bis(methan-1-yl-1- ylidene)-bis(hydrazinecarbodithioate)]  Md. Arifuzzaman*, Tasneem A. Siddiquee*, Mohammad R. Karim**, Aminul H. Mirza†, Mohamad A. Ali†, Crystal Structure: Theory and Applications, Vol.2 No.4, 159-166, 2013 [ID: 2540050].
  • Characterization of antimicrobial activities of Schiff bases derived from Phenanthroline Aldehyde and dithiocarbazates, 2013, Manuscript in preparation.
  • Synthesis and Characterization of some Schiff bases formed by Condensation of  2,9-Phenathroline-1,10-dialdehyde  with Sulfur-containing Amines;  Md. Arifuzzaman*, Mohammad R. Karim**, Tasneem A. Siddiquee*, Aminul H. Mirza†, Mohamad A. Ali†, International Journal of Organic Chemistry, 2013,  vol. 3, pp 81-86.
  • Template synthesis and X-ray structural characterization of nickel(II) and zinc(II) complexes of tetradentate SNNS ligands formed by condensation of phthalaldehyde with S-methyldithiocarbazate and 4N-methyl-3-thiosemicarbazide Mohammad Akbar Ali, Aminul Huq Mirza, Chan Chin Mei, Paul V. Bernhardt, Mohammad Rezaul Karim; Polyhedron, 2013, 49, 277-283.
  • Self-assembling dicopper(II) complexes of di-2-pyridyl ketone Schiff base ligands derived from alkyldithiocarbazates; Mohammad Akbar Ali*a, Aminul H. Mirzaa , Ray J. Butcherb , Paul V. Bernhardtc, Mohammad  Rezaul Karimd ; Polyhedron, 2011, 30(9), 1478-1485
  • Reverse NO2 reactivity in the oxidation of syringyl lignin model compounds in acetonitrile Mustakim, Sheikh S.; Karim, Mohammad R.,  240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010, ORGN-151.  
  • “2,9-Bis(1,3-benzothiazol-2-yl)-1,10-phenanthroline dichloromethane disolvate” Jesmin Akther, Sergey Lindeman and Mohammad R. Karim; Acta Cryst 2008, E64, 01836
  • "N-Oxo radicals in the oxidation of lignin model compounds" Dr. Mohammad R. Karim, Department of Chemistry, Presented at the NASA SHARP Program, June 20, 2001.
  • "Hemicholinium - 3 Mustard Reveals Two Populations of Choline Cotransporters with Different Properties." M.T.Ivy, R.F.Newkirk, M.R. Karim, C.M.P.Mtshali and J.G.Townsel, Neuroscience, 2001, 102(4), 969-978.
  • "N-Oxo radicals in the oxidation of phenolic legnin compounds" Mustakim, Shiekh and Mohammad R. Karim, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 20-21, 2000.
  • “Hemicholinium - 3 Mustard Derivative on Choline Cotransport: II. The Revelation of a Population of Silent Cotransporters; Michael T. Ivy, Robert F. Newkirk, Mohammad R. Karim, Charlie M.P. Mshatli and James G. Townsel; Neuroscience, 2000.
  • "Revelation of Silent Choline Cotransporters" M.D. Kemp, R.F. Newkirk, M.T. Ivy, M.R. Karim and J.G. Townsel; Society for Neuroscience Conference, Los Angeles, California, , Nov 7-12, 1998.
  • "Hemicholinium Mustard Reveals a Constitutive Cycling Choline Cotransporter" R.F. Newkirk, M.T. Ivy, M.R. Karim, and J.G. Townsel; Society for Neuroscience Conference, Los Angeles, California, , Nov 7-12, 1998.
  • "A Hemicholinium-3 Mustard Reveals Two Populations of Choline Cotransporters with Different Properties” Michael T. Ivy, Mohammad R. Karim, Robert F. Newkirk, Byron D. Ford and James G. Townsel; Neuroscience Abstracts, 1998, Vol 23(2), p1239.
  •  "Preparation and Nucleic-Acid Binding of Ellipticine Derivatives." Kennedy, G. D., Krishnan, G., Karim, M., and Harden, D.  (1997). Heterocyclic Communications, 2, 125-128.
  • "Pulping Catalyst From Lignin (5). Nitrogen Dioxide Oxidation of Lignin Models to Benzoquinones", Dimmel, D. R.; Karim, M.R.; Savidakis, M.C; Bozell, J.J.;  J. Wood Chem. Technol., 1996, 16, 169.
  • “Quantitative Structure-Activity Relationship Study of Taxol Analogues.” Mohammad R. Karim,  1st Biomedical Sciences And Engineering Symposium ’97, Nashville, Tennessee, August 6, 1997.
  • “Synthesis of highly functionalized allyl halides as useful synthetic intermediates.” Mohammad R. Karim and Kimberly Herron, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 24-25, 1997.
  • "Synthesis of substituted indole and carbazole derivatives via intramolecular ene reaction" Mohammad R. Karim and Xiaoming Shan*, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 24-25, 1997
  • "Approaches to the synthesis of AB ring of Taxol" Mohammad R. Karim and Seong Cho*, Department of Chemistry, College of Arts and Sciences University-Wide Research Day, March 24-25, 1997.
  • Kennedy, G. D., Krishnan, G., Karim, M., and Harden, D.  (1996).  Preparation and Nucleic-Acid Binding of Ellipticine Derivatives.  Heterocyclic Communications, 2, 125-128.
  • “Effects of Electron Donating Groups on the Ene Donor in Intramolecular Ene Reaction”, M.R. Karim, Leon Smith, at 211th National Meeting of the American Chemical Society, March 24-28, 1996, in New Orleans, Louisiana (ORGN. 42)
  • “Synthesis and Ene Reaction of Model Compounds Containing Electron Donating Groups on the Ene Donor”. Dr. Mohammad R. Karim and Leon M. Smith* and , Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 25-26, 1996
  • “Synthesis and Ene Reaction of Benzenoid Model Compounds Containing Electron Donating Groups on the Ene Donor”. Mohammad R. Karim and Jidong Li*, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 25-26, 1996
  • “Synthesis of Indole Derivatives Via Intramolecular Ene Reaction”. Mohammad R. Karim and Xiaoming Shan*, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 25-26, 1996
  • "Effects of Electron donating Groups on the ENE donor in Type III Intramolecular ENE Reaction" M.R. Karim, Leon Smith and Jidong Li, Tenn. Acad. Sc., 70:98, 1995.
  • "Effect of electron donating groups on the ene donor in type III intramolecular ene reaction", Seals, N; Whiteside, J.; Karim, M.R.* at 20th NIGMS Annual Conference, Nov 3-6,1993, in Atlanta, Georgia. Abstract No. 493.
  • "Synthesis of a New Class of Heterocyclic Compounds as Anti-Aids Drugs" , Kennedy, G.D.; Karim, M.R. Conference at Pensacola, 1992.
  • "Degradation of Dibenzodioxin during Chlorine Dioxide Bleaching of Kraft Pulp", Alison K. Daube, Mohammad R. Karim, Donald R. Karim, Thomas J. McDonough, Sujit Banerjee; Environ. Sci. Technol. 1992, 22, 1324
  • “Novel synthesis of macrocyclic keto lactones, and their utility in the construction of medium-sized carbocyclic rings via transannular aldol condensation reactions.” Karim, Mohammad Rezaul.    Diss. Abstr. Int. B 1990, 51(1), 212. 
  • "A new and Efficient Approach to Macrocyclic Ketolactones", Karim, M.R.; Sampson, P.* J. Org. Chem., 1990, 55, 598.
  • "An Improved Ozonolytic Approach to 6-Oxoheptanal", Karim, M.R.; Sampson, P.* Org. Prep.    Proc. Intl. 1990, 22, 27.
  • "Transannular Aldol Condensation Within Macrocyclic Ketolactones: A novel Approach to 8-membered Carbocyclic Rings", Karim, M.R.; Sampson, P.*, Tetrahedron Lett. 1988, 29, 6897.
  • "Structure of Tinosporide- A Furanoid Diterpene from Tinospora cordifolia Myers", Ahmad, M.; Kazi, A.B.; Karim, M.R.; J. Bang. Acad. Sci. 1978, 2, 25.
  • "Use of Transannular Aldol Condensation Reaction within Macrocyclic Ketolactones for the Construction of Medium-Sized Carbocyclic Rings", Karim, M.R.; Chai, K.B.; Sampson, P.* manuscript in preparation.
  • Use of Ti(III) Ion Peroxide-Induced Radical Addition Reaction in the Synthesis of Long-Chain Polyfunctionalized Carboxyxlic acids or Esters", Karim, M.R.; Fillippini, B. B., Sampson, P.* manuscript in preparation.
  • "Transannular Reactions Within Macrocyclic Lactones: A Novel Approach to 8-Membered Carbocyclic Rings", Mohammad R. Karim, Paul Sampson*, at 20th Central regional Meeting of the American Chemical Society, June, June 1-3, 1988, in Morgantown, West Virginia (abstr. no. 116)
  • "Transannular Reactions Within Macrocyclic Lactones: A Novel Approach to 8-Membered Carbocyclic Rings", Mohammad R. Karim, Paul Sampson*, at 196th National Meeting of the American Chemical Society, Sept. 25-30, 1988, in Los Angeles, California (ORGN. 156)
  • "An Efficient Approach to Macrocyclic Ketolactones", Mohammad R. Karim, Paul Sampson*, at 21st Central Regional Meeting of American Chemical Society, May 31st-June 2nd, 1989,Cleveland, Ohio.
  • "Use of Tritium-Labeled Dibenzo-p-Dioxin in Bleaching Kraft Pulp", Alison K. Daube, Mohammad R. Karim, Donald R. Dimmel, Thomas J. McDonough and Sujit Banerjee, at 201st National Meeting of the American Chemical Society, April 14-19, 1991, in Atlanta, Georgia (CELL 0030)

Book Review:

             1.        Fundamentals of Chemistry, Chapters 5 and 9, 3rd edition by David Goldberg, McGraw-Hill Publisher, January 2001.

             2.        Modern Organic Synthesis: An Introduction by Michael Nantz and George Zweifel W.H. Freeman and Company, Publishers. May, 2005

HONORS AND AWARDS:

  •       Department of Education Award, 1997
  •       Special recognition by MOHONA Cultural group of Atlanta, 1996
  •        Kent State University Fellowship (1989)
  •         Waldo-Semon Graduate Research Award by KSU and B.F. Goodrich.               
  •         American Chemical Society Award (1988)
  •         Dissertation award (1988) at Kent State University
  •         Teaching Fellowship (1985-89) in the Department of Chemistry, Kent State University, Kent, Ohio.               

EDUCATION:  

Ph.D.    Kent State University (Org. Chemistry), Kent, Ohio, 1989    
M.S.      Jahangirnagar University (Org. Chemistry), Dhaka, Bangladesh, 1980
B.S.      Jahangirnagar University (Chemistry), Dhaka, Bangladesh.

TEACHING :

  • ·General Chemistry
  • ·Organic Chemistry
  • ·Spectroscopic methods
  • ·Advanced Organic Chemistry
  • ·Special Topics Organic – Retrosynthetic Analysis
  • ·Scientific Communications
  • ·Organic Chemistry Survey

Detailed CV